Sulindac is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and is primarily used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis and rheumatoid arthritis. It is also used to treat bursitis, tendinitis, acute gouty arthritis, and other types of pain.
Drugs@FDA, 2006 This supplemental new drug application provides for revisions to the CLINICAL PHARMACOLOGY section of the package insert. Basic Clin Pharmacol Toxicol. 2006 Oct;99(4):294-9
Mitochondrial uncoupling by the sulindac metabolite, sulindac sulfide. Clin Ther. 2006 Aug;28(8):1123-32.
Hepatic disorders in patients treated with COX-2 selective inhibitors or nonselective NSAIDs: a case/noncase analysis of spontaneous reports.
Life Sci. 2006, Nov 10;79(24):2269-74. Epub 2006 Aug 1.Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels.
Fundam Clin Pharmacol, 2006 Aug;20(4):391-5 Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.